Slide
Welcome to the
Narcolepsy Project

NarcolepsyProject.com provides patients and family members with the latest information about sleep disorders, research initiatives, and currently enrolling clinical trials.

Slide
Welcome to the
Narcolepsy Project

NarcolepsyProject.com provides patients and family members with the latest information about sleep disorders, research initiatives, and currently enrolling clinical trials.

Slide
Welcome to the
Narcolepsy Project

NarcolepsyProject.com provides patients and family members with the latest information about sleep disorders, research initiatives, and currently enrolling clinical trials.

Slide
Welcome to the
Narcolepsy Project

NarcolepsyProject.com provides patients and family members with the latest information about sleep disorders, research initiatives, and currently enrolling clinical trials.

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Narcolepsy Study

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Click the green button above to search for a study near you.

Recently Added

Click the study name or NCT# to find out more info about each study.

ALKS-2680

Low Sodium Oxybate

MK-6552

pitolisant

reboxetine

Low Sodium Oxybate

Low Sodium Oxybate

TAK-861

NCT # NCT06358950NCT05837091NCT06179407NCT02611687NCT05113745NCT05875974NCT05869773NCT05816382
What is the main factor the study is measuring?
What is the main factor the study is measuring?Excessive Daytime SleepinessTotal Sleep Time Adverse EventsExcessive Daytime SleepinessNumber of Cataplexy EventsEpworth Sleepiness ScaleBlood PressureAdverse Events
Diagnosis
DiagnosisNT1 IH NT1 NT1, NT2 NT1 NT1, NT2, IH NT1, NT2 NT1, NT2
Study Phase
Study PhasePhase II Phase IV Phase I Phase III Phase III Phase IV Phase IV Phase II and III
Important criteria to be able to participate
Important criteria to be able to participateBMI 18-35, HLA positive Total Sleep Time (9 or more hours) PSG/MSLT verified diagnosis, HLA positive Narcolepsy diagnosis Completed AXS-12-301 study PSG/MSLT verified diagnosis, Epworth Sleepiness Scale > 10 Actively taking Xyrem 6-9g/nt Completed previous TAK-861 study
Mechanism
MechanismOrexin GABA / GHB UNK Histamine (H3) Norepinephrine GABA / GHB GABA / GHB Orexin
Age Range
Age Range18 to 70 18 to 65 18 to 55 6 to 18 15-75 18-75 18-70 US: 18-70; Japan: 16-70
Daytime Testing Required
Daytime Testing RequiredYes Yes Yes No No No No Yes
Overnight Stays Required
Overnight Stays RequiredYes Yes Yes No No Yes Yes Yes
Max Study Duration
Max Study Duration15 weeks 3 months 5 weeks 8 weeks 28 weeks 21 weeks 6 weeks 108 weeks
Is there a possibility of receiving placebo?
Is there a possibility of receiving placebo?Yes No Yes Yes YES (open-label follows double-blind) No No No
Trade Name
Trade NameNot Published Xywav Not Published Wakix Edronax (in Europe) Xywav Xywav Not Published
Drug Formulation
Drug FormulationTablet Liquid Capsule Tablet Tablet Liquid Liquid Tablet
Will I be compensated financially for my participation?
Will I be compensated financially for my participation?Yes Yes Yes Yes Yes Yes Yes Yes
Can I have other sleep disorders during the trial?
Can I have other sleep disorders during the trial?No No No No No No No No
Where is the trial being conducting (Region / # of sites)
Where is the trial being conducting (Region / # of sites)US (5) US (4) US (1) EU (11) US (26) Canada (1) UNK US (22) EU (10) US (25) EU (32) Asia (11)
Is this an open label study?
Is this an open label study?Yes Yes Yes No Yes Yes No Yes

Information & research

Find out common sleep and research terminology to help you understand your disorder.

TREATMENT OPTIONS

Medications used to treat narcolepsy and hypersomnia symptoms.

FIND A STUDY

Find out which clinical trials are currently active for narcolepsy.

Need more Information?

Click on the button links below to learn more about sleep disorders, find a board-certified sleep doctor, and find online guides to help you understand your disorder. You can also find information on our Narcolepsy Knowledge page.