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Welcome to the
Narcolepsy Project

NarcolepsyProject.com provides patients and family members with the latest information about sleep disorders, research initiatives, and currently enrolling clinical trials.

Slide
Welcome to the
Narcolepsy Project

NarcolepsyProject.com provides patients and family members with the latest information about sleep disorders, research initiatives, and currently enrolling clinical trials.

Slide
Welcome to the
Narcolepsy Project

NarcolepsyProject.com provides patients and family members with the latest information about sleep disorders, research initiatives, and currently enrolling clinical trials.

Slide
Welcome to the
Narcolepsy Project

NarcolepsyProject.com provides patients and family members with the latest information about sleep disorders, research initiatives, and currently enrolling clinical trials.

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Narcolepsy Study

Comparison Table

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Click the green button above to search for a study near you.

Recently AddedRecently AddedRecently AddedRecently Added

Click the study name or NCT# to find out more info about each study.

ALKS 2680

TAK-360

ORX750

ALKS 2680

TBA

Solriamfetol

ALKS-2680

FT218

E2086

TAK-861

TAK-861

ALKS-2680

Low Sodium Oxybate

Pitolisant

MK-6552

reboxetine

Low Sodium Oxybate

TAK-861

mazindol

Low Sodium Oxybate

NCT # NCT06843590NCT06812078NCT06752668NCT06767683First Light StudyNCT06590662NCT06555783NCT06525077NCT06462404NCT06505031NCT06470828NCT06358950NCT05837091NCT02611687NCT06179407NCT05113745NCT05875974NCT05816382NCT05914194NCT05869773
What is the main factor the study is measuring?
What is the main factor the study is measuring?Excessive Daytime SleepinessTolerance, Dose Finding, Excessive Daytime SleepinessAdverse Events, Changes in Laboratory Tests, Vital Signs, ECGAdverse Events4 or more cataplexy events weeklyExcessive Daytime SleepinessExcessive Daytime SleepinessExcessive Daytime SleepinessExcessive Daytime SleepinessExcessive Daytime SleepinessExcessive Daytime SleepinessExcessive Daytime SleepinessTotal Sleep Time Excessive Daytime Sleepiness Adverse EventsNumber of Cataplexy EventsEpworth Sleepiness ScaleAdverse Events. Excessive Daytime Sleepiness# Cataplexy EventsBlood Pressure
Diagnosis
DiagnosisIH IH NT1, NT2, IH NT1, NT2 NT1 IH NT2 IH NT1 NT1 NT1 NT1 IH NT1, NT2 NT1 NT1 NT1, NT2, IH NT1, NT2 NT1 NT1, NT2
Study Phase
Study PhasePhase II Phase II Phase II Phase II, III UNK Phase II Phase II Phase III Phase I Phase III Phase III Phase II Phase IV Phase III Phase I Phase III Phase IV Phase II and III Phase III Phase IV
Important criteria to be able to participate
Important criteria to be able to participateDiagnosed IH within the previous 10 years Diagnosed IH, BMI 16-38 with minimum weight 40kg Diagnosis of NT1, NT2, or IH, BMI 17-37 Completed ALKS 2680-201 (Vibrance-1) or ALKS 2680-202 (Vibrance-2) Diagnosis of NT1 BMI 18 to 30, Epworth Sleepiness Scale >11 Diagnosis of NT2, BMI 18-35 Diagnosis of Idiopathic Hypersomnia, TST 7+ hours Diagnosis of NT1, BMI 18-40 Diagnosis of NT1, HLA positive, BMI 18-40 Diagnosis of NT1, HLA positive, BMI 18-40 BMI 18-35, HLA positive Total Sleep Time (9 or more hours) Diagnosis of NT1 or NT2 PSG/MSLT verified diagnosis, HLA positive Completed AXS-12-301 study PSG/MSLT verified diagnosis, Epworth Sleepiness Scale > 10 Completed previous TAK-861 study 4+ cataplexy events per wk, BMI 18-40 Actively taking Xyrem 6-9g/nt
Mechanism
MechanismOrexin Orexin Orexin Orexin UNK Dopamine-Norepinephrine Reuptake Inhibition Orexin GABA / GHB Orexin Orexin Orexin Orexin GABA / GHB Histamine (H3) receptor antagonist/inverse agonist UNK Norepinephrine GABA / GHB Orexin orexin, dopamine, norepinephrine GABA / GHB
Age Range
Age Range18 to 70 18 to 70 18 to 65 18 to 70 18 to 70 18 to 60 18 to 70 18 to 75 18 plus 16 to 70 16 to 70 18 to 70 18 to 65 6 to 18 18 to 55 15-75 18-75 US: 18-70; Japan: 16-70 18+ 18-70
Daytime Testing Required
Daytime Testing RequiredUNK UNK Yes Yes UNK Yes Yes No Yes Yes Yes Yes Yes No Yes No No Yes No No
Overnight Stays Required
Overnight Stays RequiredN/A N/A N/A N/A N/A No Yes No Yes Yes Yes Yes Yes No Yes No Yes Yes No Yes
Max Study Duration
Max Study Duration8 wks 8 wks 49 days 100 weeks 14 to 23 weeks 7 weeks 21 weeks 42 weeks up to 48 days 12 weeks 12 weeks 15 weeks 3 months 12 weeks followed by extended treatment 5 weeks 28 weeks 21 weeks 108 weeks 8 wks 6 weeks
Is there a possibility of receiving placebo?
Is there a possibility of receiving placebo?Yes Yes Yes No Yes Yes Yes Yes Yes Yes Yes Yes No Yes Yes YES (open-label follows double-blind) No No Yes No
Trade Name
Trade NameNot Published Not Published Not Published Not Published Not Published Sunosi Not Published Lumryz Not Published Not Published Not Published Not Published Xywav Wakix Not Published Edronax (in Europe) Xywav Not Published Sanorex/Quilience Xywav
Drug Formulation
Drug FormulationTablet Tablet Capsule Tablet UNK Tablet Tablet Tablet Tablet Tablet Tablet Tablet Liquid Tablet Capsule Tablet Liquid Tablet Tablet Liquid
Will I be compensated financially for my participation?
Will I be compensated financially for my participation?Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes
Can I have other sleep disorders during the trial?
Can I have other sleep disorders during the trial?Yes No No N/A No No No No No No No No No No No No No No No No
Where is the trial being conducting (Region / # of sites)
Where is the trial being conducting (Region / # of sites)Not Available Not Available US (1) US (5) US (15) CAN (2) EU (1) Not Available US (6) US (13) Canada (2) Not Available US, Canada - # TBD US (5) US (4) EU (11) US (1) US (26) Canada (1) UNK US (25) EU (32) Asia (11) US (25 planned) US (22) EU (10)
Is this an open label study?
Is this an open label study?No No No Yes No No Yes Yes No No No Yes Yes Yes Yes Yes Yes Yes No No

Information & research

Find out common sleep and research terminology to help you understand your disorder.

TREATMENT OPTIONS

Medications used to treat narcolepsy and hypersomnia symptoms.

FIND A STUDY

Find out which clinical trials are currently active for narcolepsy.

Need more Information?

Click on the button links below to learn more about sleep disorders, find a board-certified sleep doctor, and find online guides to help you understand your disorder. You can also find information on our Narcolepsy Knowledge page.